Encapsulation of mepivacaine prolongs the analgesia provided by sciatic nerve blockade in mice
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چکیده
منابع مشابه
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injecte...
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this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
The effect of CCK receptor agonists and antagonists in sciatic nerve-ligated mice
The effects of caerulin, a CCK receptor agonist, and proglumide, a receptor antagonist, on hyperalgesia induced by sciatic nerve ligation, was studied in mice. Tolerance to the morphine response was obtained 3,7, 14,21 and 28 days after unilateral sciatic nerve ligation. Maximum hyperalgesia was found 14 days after nerve ligation. Caerulin increased morphine antinociception in nerve-ligated ani...
متن کاملIncreased visceral pain responsiveness in female mice compared to male mice afer partial sciatic nerve ligation
Neuropathic pain which is a chronic pain causes hyperalgesia due to peripheralm nerve damage.the relation between neuropathic pain and hyperalgesia and the response to treatment in case of somatic and inflammatory pain have been investigated previuosly.however the response of visceral pain in peripheral neuropathy and the possible gender differences in visceral pain response and gender differnc...
متن کاملPerineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current.
BACKGROUND The current study was designed to test the hypothesis that the increased duration of analgesia caused by adding dexmedetomidine to local anesthetic results from blockade of the hyperpolarization-activated cation (I(h)) current. METHODS In this randomized, blinded, controlled study, the analgesic effects of peripheral nerve blocks using 0.5% ropivacaine alone or 0.5% ropivacaine plu...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia
سال: 2004
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03018399